Font Font Revolution
I can honestly say that I've never given ClearType a chance. I've guess I've gotten used to the crappy rendering I've grown up with. So now I'm going to give it a try. I turned ClearType on and tweaked it to my liking (with the ClearType PowerToy).
The new font, Consolas, that ships with Vista seems very cool. A good monospaced typeface like Consolas is important because lengthy on-screen reading while programming can quickly tire the eyes.
Here is a link to an article that discusses all of the new fonts included with Windows Vista. If you still can't get enough typography, I suggest checking out fontblog.